化工社化工社 化学情報印刷レポート · 研究参考用
p-Bromobenzenesulfonyl chloride → 4-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| 反応物 | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| 反応物 | 2-Amino-3-phenylbutanoic acid | HCID 64808 | — |
| 反応物 | D-Isoleucine | HCID 76551 | — |
| 反応物 | Alloisoleucine, DL- | HCID 99288 | — |
| 反応物 | (S)-2-amino-2,3-dimethylbutanoic acid | HCID 7408715 | — |
| 生成物 | 4-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide | HCID 10337067 | — |
反応手順
The following compounds (Examples 33–39, Table 5) were prepared using 4-bromobenzenesulfonyl chloride, and 4-chlorobenzenesulfonyl chloride, with D-isoleucine, L-α-methyl-valine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 33. This procedure is outlined in the following Scheme.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07166622B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-584039e801454c479c6577ce1f234983 |
| 出典メモ | uspto-grants-2007_01 |