methyl 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoate → 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

HRID 13755ノート

反応式

HRID 13755 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:21])[C:11]=1[CH2:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH3:20])[CH3:19])[CH2:14]1)[C:5]([O:7]C)=[O:6]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:21])[C:11]=1[CH2:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH3:19])[CH3:20])[CH2:14]1)[C:5]([OH:7])=[O:6]

参加物

3

反応物 1

HCID 68694023methyl 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoate

生成物 1

HCID 686902813,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that methyl 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoate obtained in the step 3 was used and methanol was used as the solvent, and that after methanol was added to the residue and the resulting mixture was stirred, insolubles were removed by filtration and the solvent in the filtrate was distilled off under reduced pressure to obtain the objective compound.

後処理

  1. customobtained in the step 3
  2. custominsolubles were removed by filtration
  3. distillationthe solvent in the filtrate was distilled off under reduced pressure
  4. customto obtain the objective compound

出典と根拠

ORDレコード
ord-b7e88198fb3f4159871c12ceae7412d9
出典データセット
uspto-grants-2010_06
特許番号
US07728131B2

反応ノート

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