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Sodium Hydroxide → 5-Methyl-3-phenylisoxazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 5-methyl-3-phenyl-1,2-oxazole-4-carboxylate | HCID 727920 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Methyl-3-phenylisoxazole-4-carboxylic acid | HCID 14343 | 72% |
反応手順
To 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (0.853 g, 3.69 mmol) in methanol (12 mL) was added 2N NaOH (8 mL) the reaction solution was stirred at ambient temperature for 60 hr. The solution was dilute with water and extracted twice with ethyl acetate. The combined extract was washed with brine and dried over MgSO4 and concentrated. Recrystallization (hexanes/ethyl acetate) afforded a white solid (0.540 g, 72% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07169798B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-b96d7a5e95cf41579c754086b5928b63 |
| 出典メモ | uspto-grants-2007_01 |