HCID 23145989、化合物 → HCID 23145982、化合物
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][C:10]=2[C:20]([F:23])([F:22])[F:21])[CH2:4][CH2:3]1>CO>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]=2[C:20]([F:21])([F:23])[F:22])[CH2:6][CH2:7]1参加物
3
試薬・触媒・溶媒 1
実験手順
This compound was prepared in the same manner as in Reference Example 1 (step 6), except that ethyl 4-(1-methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoate obtained in the step 1 was used, and that the crude product was mixed with methanol and stirred, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized by adding acetonitrile.
後処理
- customobtained in the step 1
- custominsolubles were removed by filtration
- distillationthe filtrate was distilled off under reduced pressure
- customthe residue was crystallized
- additionby adding acetonitrile
出典と根拠
- ORDレコード
- ord-566edd5b8b8c4f61ba505a198e9a2476
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728131B2
反応ノート
読み込み中…