t-Butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate → HCID 23145928、化合物
反応式
[F:1][CH:2]([F:24])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[CH2:16][N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[C:6]([O:8]C(C)(C)C)=[O:7]>CO>[F:24][CH:2]([F:1])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[CH2:16][N:17]1[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]1)[C:6]([OH:8])=[O:7]参加物
3
実験手順
This compound was prepared in the same manner as in Reference Example 1 (step 6), except that t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate obtained in the step 5 was used, and that the resulting crude product was mixed with methanol, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized from acetonitrile.
後処理
- customobtained in the step 5
- customwere removed by filtration
- distillationthe filtrate was distilled off under reduced pressure
- custom