2-Butyl-2-(3,5-dimethoxy-phenyl)-[1,3]dithiolane → 2-Cycloheptyl-2-(3,5-dimethoxy-phenyl)-[1,3]dithiolane

HRID 1376243

反応式

HRID 1376243 の反応式
[CH:1]1([C:8]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[CH:11]=2)=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(C1(C2C=C(OC)C=C(OC)C=2)[S:28][CH2:27][CH2:26][S:25]1)CCC>CCCCCC.C(OCC)(=O)C>[CH:1]1([C:8]2([C:10]3[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[CH:11]=3)[S:28][CH2:27][CH2:26][S:25]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 3176902-Butyl-2-(3,5-dimethoxy-phenyl)-[1,3]dithiolaneHCID 66884835Cycloheptyl-(3,5-dimethoxy-phenyl)-methanone

生成物 1

HCID 858840932-Cycloheptyl-2-(3,5-dimethoxy-phenyl)-[1,3]dithiolane

試薬・触媒・溶媒 1

HCID 21226206Ethyl acetate hexane溶媒

実験手順

Compound 12 was prepared from Compound 8 using the same procedure as described above for Compound 9. Yield 3.60 g (79.2%) as an oil. Rf=0.56 (hexane:ethyl acetate 92:8); IR (neat) 2925, 1206, 1067, 832, 693 cm−1; 1H NMR δ 6.94 (d, J=2.4 Hz, 2H), 6.32 (t, J=2.25 Hz, 1H), 3.80 (s, 6H), 3.31–3.10 (m, 4H), 2.40–2.32 (m, 1H), 1.96–1.30 (m, 12H). 13C NMR δ 160.38, 148.94, 106.52, 98.48, 81.99, 70.21, 55.60, 51.27, 45.22, 39.34, 32.82, 29.80, 28.04, 27.77; MS: (ESI, Pos.) m/z 361 ([M+23]+).

出典と根拠

ORDレコード
ord-fb158e112f41402689a7516e1fe8a338
出典データセット
uspto-grants-2007_01
特許番号
US07169942B2

関連ノート

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