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5-(2-Butyl-1,3-dithiolan-2-yl)benzene-1,3-diol → 5-(2-Cyclohexyl-[1,3]dithiolan-2-yl)-benzene-1,3-diol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(2-Butyl-1,3-dithiolan-2-yl)benzene-1,3-diol | HCID 317695 | — |
| 反応物 | 2-Cyclohexyl-2-(3,5-dimethoxy-phenyl)-[1,3]dithiolane | HCID 85884091 | — |
| 溶媒 | Ethyl acetate hexane | HCID 21226206 | — |
| 生成物 | 5-(2-Cyclohexyl-[1,3]dithiolan-2-yl)-benzene-1,3-diol | HCID 85884100 | — |
反応手順
Compound 18 was prepared from Compound 11 using the same procedure as described above for Compound 16. Yield 0.853 g (62.2%) as a waxy solid. Rf=0.27 (hexane:ethyl acetate 8:2); 1H NMR δ 6.78 (d, J=0.9 Hz, 2H), 6.19 (t, J=1.95 Hz, 1H), 4.14 (br s, 2H), 3.32–3.07 (m, 4H), 2.15–2.06 (m, 1H), 1.96–1.58 (m, 4H), 1.19–1.00 (m, 4H); 13C NMR δ 156.95, 147.94, 107.39, 101.12, 80.58, 60.83, 50.56, 38.82, 30.92, 26.77, 26.24, 21.08, 14.17; MS: (ESI, Neg.) m/z 295 ([M−H]−).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07169942B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-e72c13d807084fbf9fabfd0c3516afa4 |
| 出典メモ | uspto-grants-2007_01 |