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Potassium Carbonate → 1-[(Trimethylsilyl)methyl]-4-chloro-3-(2-nitro-3-chlorophenyl)pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Silane, (chloromethyl)trimethyl- | HCID 75361 | — |
| 反応物 | HCID 178526739 | HCID 178526739 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethylacetate heptane | HCID 21899848 | — |
| 生成物 | 1-[(Trimethylsilyl)methyl]-4-chloro-3-(2-nitro-3-chlorophenyl)pyrazole | HCID 22916488 | — |
反応手順
0.85 g of anhydrous potassium carbonate is added to a solution of 1.30 g of 4-chloro-3-(2-nitro-3-chlorophenyl)pyrazole and 0.70 g of (trimethylsilyl)methyl chloride in 30 ml of N,N-dimethylformamide. The reaction mixture is stirred for 12 hours at room temperature and diluted with 100 ml of an ether/H2O (1/1) mixture. The ether phase is dried over MgSO4 and concentrated under reduced pressure. The residual oil is purified by liquid chromatography on a Silica column (eluent: heptane/ethyl acetate [50/50]).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05663119 |
| 出典データセット | uspto-grants-1997_09 |
| ORD ID | ord-8c638eb01e474d6d8a47ec2efe57952c |
| 出典メモ | uspto-grants-1997_09 |