N-(tert-Butoxycarbonyl)-4-cyano-L-phenylalanine → Diisopropylether ethyl acetate

HRID 1376684

反応式

HRID 1376684 の反応式
[C:1](N[C@H](C(O)=O)CC1C=CC(C#N)=CC=1)(OC(C)(C)C)=O.NCC(N[C@H](C(N[C@H:39]([C:43]([O:45][C:46]([CH3:49])([CH3:48])C)=O)C(C)C)=O)[CH2:28][C:29](=[O:35])[O:30][C:31](C)(C)[CH3:32])=O>>[C:29]([O:30][CH2:31][CH3:32])(=[O:35])[CH3:28].[CH:46]([O:45][CH:43]([CH3:39])[CH3:1])([CH3:48])[CH3:49]

参加物

3

反応物 2

HCID 7020841N-(tert-Butoxycarbonyl)-4-cyano-L-phenylalanineHCID 15674413HCID 15674413、化合物

生成物 1

HCID 22281796Diisopropylether ethyl acetate収率 66%

実験手順

By coupling rac N-Boc-3-(p-cyanophenyl)alanine (French Published Specification 2593 814) and H-Gly-Asp(OtBu)-Val-OtBu there is obtained [N-Boc-3-(p-cyanophenyl)-DL-alanyl]-Gly-Asp(OtBu)-Val-OtBu, m.p. 140°-145° C. from ethyl acetate/isopropyl ether, yield: 66%.

出典と根拠

ORDレコード
ord-60701ebac5fd488ab6e9f9299269e1e3
出典データセット
uspto-grants-1997_09
特許番号
US05663297

関連ノート

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