Water → 3-Bromo-1-methyl-5-methylamino-4-nitropyrazole
反応式
[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5](Br)[N:4]([CH3:11])[N:3]=1.[CH3:12][NH2:13].O>C(O)C>[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5]([NH:13][CH3:12])[N:4]([CH3:11])[N:3]=1参加物
5
実験手順
2 g (7.02 mmoles) of 3,5-dibromo-1-methyl-4-nitropyrazole are heated in 50 ml of a 40-percent solution of methylamine in ethanol for 4 hours at boiling temperature. After cooling, 100 ml water are added to the reaction mixture, the separated product is filtered out and washed with a small amount of water (20 ml). After vacuum drying, 1.45 g (88 percent of theory) of 3-bromo-1-methyl-5-methylamino-4-nitropyrazole are obtained in the form of yellow crystals with a melting point of 185° C.
後処理
- temperatureAfter cooling
- filtrationthe separated product is filtered out
- washwashed with a small amount of water (20 ml)
- customAfter vacuum drying
出典と根拠
- ORDレコード
- ord-62fcf2aa32fe4b1d98d026f06dd4b639
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05663366
反応ノート
読み込み中…