Water → 3-Bromo-5-tert-butylamino-1-methyl-4-nitropyrazole

HRID 1376880ノート

反応式

HRID 1376880 の反応式
[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5](Br)[N:4]([CH3:11])[N:3]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].O>C(O)C>[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5]([NH:16][C:12]([CH3:15])([CH3:14])[CH3:13])[N:4]([CH3:11])[N:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 229186383,5-Dibromo-1-methyl-4-nitro-1H-pyrazole

生成物 1

HCID 229186363-Bromo-5-tert-butylamino-1-methyl-4-nitropyrazole収率 78%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.5 g (5.26 mmoles) of 3,5-dibromo-1-methyl-4-nitropyrazole are heated in a solution of 20 ml tert-butylamine in 30 ml ethanol for 20 hours at boiling temperature. After cooling, the reaction mixture is poured on 150 ml water, the separated product is filtered and washed with 100 ml water. After vacuum drying, 1.14 g (78 percent of theory) of 3-bromo-5-tert-butylamino-1-methyl-4-nitropyrazole are obtained in the form of pale yellow flakes with a melting point of 75° to 77° C.

後処理

  1. temperatureAfter cooling
  2. filtrationthe separated product is filtered
  3. washwashed with 100 ml water
  4. customAfter vacuum drying

出典と根拠

ORDレコード
ord-43088b64693c4cccbbd6a2c1eb4dfd17
出典データセット
uspto-grants-1997_09
特許番号
US05663366

反応ノート

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