化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → 3-Bromo-1-(2'hydroxyethyl)-5-methylamino-4-nitropyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 3,5-Dibromo-1-(2'-hydroxyethyl)-4-nitropyrazole | HCID 13007236 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Bromo-1-(2'hydroxyethyl)-5-methylamino-4-nitropyrazole | HCID 22918627 | 91% |
反応手順
3.15 g (10 mmoles) of 3,5-dibromo-1-(2'-hydroxyethyl)-4-nitropyrazole are heated in 70 ml of a 30-percent solution of methylamine in water for 1 hour at 60° C. After cooling, the product precipitates in the form of bright yellow crystals with a melting point of 158° to 160° C. 2.4 g (91 percent of theory) of 3-bromo-1-(2'hydroxyethyl)-5-methylamino-4-nitropyrazole are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05663366 |
| 出典データセット | uspto-grants-1997_09 |
| ORD ID | ord-248d8ac453d94604bf63cb5067b16b07 |
| 出典メモ | uspto-grants-1997_09 |