Water → 4-Methyl-2-trifluoroacetyloxazole
反応式
[F:1][C:2]([F:11])([F:10])[C:3](N1C=CN=C1)=[O:4].[CH3:12][C:13]1[N:14]=[C:15]([Si](C)(C)C)[O:16][CH:17]=1.O>C(OCC)C>[CH3:12][C:13]1[N:14]=[C:15]([C:3](=[O:4])[C:2]([F:11])([F:10])[F:1])[O:16][CH:17]=1参加物
5
実験手順
1-Trifluoroacetylimidazole (10 g) was added to a stirred solution of 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. After 20 hours, water was added. The organic phase was separated, dried and evaporated and the residue was purified by flash chromatography to give the title compound as the corresponding hydrate.
後処理
- customThe organic phase was separated
- customdried
- customevaporated
- customthe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-0c8d181e4d924edba3ee1e5515808eb9
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05665747
反応ノート
読み込み中…