Hydrochloric Acid → 2H-1,4-Benzoxazin-3(4H)-one, 4-(4-piperidinyl)-

HRID 1377682ノート

反応式

HRID 1377682 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][CH2:16][C:15]2=[O:24])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[O:17][CH2:16][C:15]2=[O:24])[CH2:12][CH2:13]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 223806764-(3-Oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 222938102H-1,4-Benzoxazin-3(4H)-one, 4-(4-piperidinyl)-

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

4-(1-tert-butyloxycarbonyl-4-piperidinyl)-(2H)-1,4-benzoxazin-3(4H)-one from Step 4 was N-deprotedcted with HCl in EtOAc using the procedure given in Step 4 of Example 1. The hydrochloride salt of 4-(4-piperidinyl)-(2H)-1,4-benzoxazin-3(4H)-one was obtained as a solid (95% yield).

出典と根拠

ORDレコード
ord-63bc2a7525ec460a945f91c4b6749aa4
出典データセット
uspto-grants-1997_09
特許番号
US05665719

反応ノート

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