Hydrochloric Acid → 1-(4-Piperidyl)-4-phenyl-3,1-benzoxazin-2-one hydrochloride
反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:16][C:15]2=[O:30])[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:31]>C(OCC)(=O)C>[ClH:31].[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:16][C:15]2=[O:30])[CH2:12][CH2:13]1参加物
4
実験手順
1-(1-Boc-4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one from Step 3 above (1.97 g, 4.67 mmol) was stirred in ethyl acetate in an ice bath, then saturated with HCl gas and stirred another 15 min in the cold. The mixture was evaporated in vacuo. Three portions of ethyl acetate were successively added and evaporated in vacuo to give 1-(4-piperidyl)-4-phenyl-3,1-benzoxazin-2-one hydrochloride.