Hydrochloric Acid → HCID 70078313、化合物
反応式
[CH2:1]([N:5]([CH2:10][C:11]1[O:15][N:14]=[C:13]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)[N:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4].[ClH:33]>C(O)C>[ClH:33].[CH2:1]([N:5]([CH2:10][C:11]1[O:15][N:14]=[C:13]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)[N:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4]参加物
4
実験手順
1.17 g (0.0027 mol) of 3-(5-dibutylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 30 ml of ethanol were treated with 0.65 ml (0.0031 mol) of 3.7N ethanolic hydrochloric acid. The solvent was freed completely from solvent and the residue was recrystallized from acetone. There was obtained 0.87 g (69%) of 3-(5-dibutylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6- one hydrochloride as white crystals; m.p. 183°-185°.