Methyl formate → N-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-ylmethyl)-formamide

HRID 1378117ノート

反応式

HRID 1378117 の反応式
[NH2:1][CH2:2][C:3]1[N:7]=[C:6]([CH2:8][N:9]([CH2:13][CH2:14][CH3:15])[CH2:10][CH2:11][CH3:12])[O:5][N:4]=1.[CH:16](OC)=[O:17]>>[CH2:10]([N:9]([CH2:8][C:6]1[O:5][N:4]=[C:3]([CH2:2][NH:1][CH:16]=[O:17])[N:7]=1)[CH2:13][CH2:14][CH3:15])[CH2:11][CH3:12]

参加物

3

反応物 2

HCID 7865Methyl formateHCID 22914390HCID 22914390、化合物

生成物 1

HCID 22914380N-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-ylmethyl)-formamide収率 79%

実験手順

A solution of 15.6 g (73.5 mmol) of (3-aminomethyl-1,2,4-oxadiazol-5-ylmethyl)-dipropylamine in 100 ml of methyl formate was heated at reflux for seven hours. Subsequently, the solution was evaporated and the residue was chromatographed (silica gel, methylene chloride/methanol 19:1). There were obtained 14 g (79%) of N-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-ylmethyl)-formamide, Rf=0.28 (silica gel, methylene chloride/methanol 19:1).

後処理

  1. temperatureat reflux for seven hours
  2. customSubsequently, the solution was evaporated
  3. customthe residue was chromatographed (silica gel, methylene chloride/methanol 19:1)

出典と根拠

ORDレコード
ord-fdd359d1c4c64c1fbac2655a72940714
出典データセット
uspto-grants-1997_09
特許番号
US05665718

反応ノート

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