1-Benzylpiperazine → 1-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

HRID 1378329

反応式

HRID 1378329 の反応式
[O:1]([C:8]([CH3:13])([CH3:12])[C:9](Cl)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[O:1]([C:8]([CH3:13])([CH3:12])[C:9]([N:24]1[CH2:25][CH2:26][N:21]([CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:22][CH2:23]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 759941-BenzylpiperazineHCID 131111912-Methyl-2-phenoxypropanoyl chloride

生成物 1

HCID 106169921-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 0.01 mol of 2-phenoxyisobutyric acid chloride (obtained by reaction of thionyl chloride with 2-phenoxyisobutyric acid) in 100 ml of methylene chloride is introduced into an Erlenmeyer flask containing a solution of 0.01 mol of 1-benzylpiperazine in 100 ml of methylene chloride. The mixture is stirred for 5 hours at room temperature, filtered and evaporated to dryness. The residue is taken up in water, basified and extracted with chloroform. The organic phases are combined, dried and evaporated.

後処理

  1. filtrationfiltered
  2. customevaporated to dryness
  3. extractionextracted with chloroform
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-3bcfaea19aaf46f69f08e67cfa8e5548
出典データセット
uspto-grants-1997_09
特許番号
US05668138

関連ノート

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