Benzylamine → (2S)-2-[(tert-butoxy)carbonylamino]-3-(2-naphthyl)-N-benzylpropanamide
反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([NH:16][C@H:17]([C:29](O)=[O:30])[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>>[C:9]([NH:16][C@H:17]([C:29]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:30])[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)([O:11][C:12]([CH3:14])([CH3:13])[CH3:15])=[O:10]参加物
3
実験手順
In substantially the same manner as Working Example 2, benzylamine (0.93 g) was condensed with Boc-3-(2-naphthyl)-L-alanine (2.50 g) to give N-(Boc-3-(2-naphthyl)-L-alanyl)benzylamine (3.0 g) as white crystals (yield 94%). The Boc group of the product was deprotected by using 4N hydrochloric acid/ethyl acetate solution, and 1.82 g of thus-obtained compound was condensed, in substantially the same manner as Working Example 2, with Compound 1 (1.47 g) to give the above-titled compound (Compound 109; 0.85 g) as white crystals (yield 29%).
出典と根拠
- ORDレコード
- ord-d8487c27c2634f2abaea8a60fa8cb91b
- 出典データセット