4-Chloro-6-methoxypyrimidine → HCID 21753096、化合物

反応式

Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[CH:4][N:3]=1.[CH3:10][CH:11]([NH2:20])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>>[CH3:10][CH:11]([NH:20][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[CH:4][N:3]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

反応物 2

HCID 10515094-Chloro-6-methoxypyrimidine

HCID 22035449Decan-2-amine

生成物 1

HCID 21753096HCID 21753096、化合物収率 60.3%

実験手順

7.2 g (0.05 mol ) of 4-chloro-6-methoxypyrimidine and 15.7 g (0.1 mol) of 2-decylamine were heated at 100° C. for 2 hours. The mixture was worked up using a water/methylene chloride mixture, and purification by chromatography (silica gel/ethyl acetate) gave 8.0 g (58.8% of theory) of 4-(2-decylamino)-6-methoxypyrimidine in the form of a yellow oil.

後処理

customa water/methylene chloride mixture, and purification by chromatography (silica gel/ethyl acetate)

出典と根拠

ORDレコード: ord-7ec57e0e22264adfb7a814f08e2c24d5
出典データセット: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05668140

反応ノート

読み込み中…

参加物