Dimethylamine → N,N-dimethyl-3-nitropyridin-2-amine
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:11][NH:12][CH3:13].O>CCO>[CH3:11][N:12]([CH3:13])[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1参加物
5
実験手順
A stirred mixture of 2-chloro-3-nitropyridine (1.00 g, 0.00631 mol) in absolute EtOH (17 ml), under nitrogen, was treated, dropwise during 10 minutes, with 3.86 g (0.0214 mol) of 25% aqueous dimethylamine and kept at ambient temperature (25° C.) for 30 minutes. The mixture was mixed with water and extracted with EtOAc. The extract was washed with water, dried (MgSO4) and concentrated to give 1.05 g of the titled product, a yellow oil.
後処理
- customkept at ambient temperature
- custom(25° C.)
- customfor 30 minutes
- extractionextracted with EtOAc
- washThe extract was washed with water
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1ff17f8b64874cc1b3708b067b12b3b5
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05668157
反応ノート
読み込み中…