Acetyl chloride → HCID 178497913、化合物

HRID 1378699ノート

反応式

HRID 1378699 の反応式
[C:1](Cl)(=O)C.[OH:5][C:6]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[C:8]([CH3:15])[N:7]=1>CO>[CH3:1][O:13][C:12]([C:11]1[C:6]([OH:5])=[N:7][C:8]([CH3:15])=[CH:9][CH:10]=1)=[O:14]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 178425908HCID 178425908、化合物

生成物 1

HCID 178497913HCID 178497913、化合物収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Acetyl chloride (50 ml) was added cautiously to a stirred suspension of 2-hydroxy-6-methylpyridine-3-carboxylic acid (14.3 g, 93.44 mmol) in dry methanol (500 ml) and the resulting solution was heated to reflux. After 16 h the solution was evaporated in vacuo to give the title compound (15.62 g, 100%) as a solid: 1H NMR (DMSO) shows the methyl singlet at δ 3.71.

後処理

  1. temperaturethe resulting solution was heated to reflux
  2. customAfter 16 h the solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-9892c3ce260e405e984e4a33138acbd3
出典データセット
uspto-grants-1997_09
特許番号
US05668289

反応ノート

読み込み中…