Hydrochloric Acid → HCID 135829371、化合物
反応式
C1(C[O:5][C:6]2[C:7]3[C:11]([CH:12]=[CH:13][CH:14]=2)=[N:10][N:9]([CH3:15])[C:8]=3[S:16]([NH2:19])(=[O:18])=[O:17])CC1.Cl>C(O)(=O)C>[OH:5][C:6]1[C:7]2[C:11]([CH:12]=[CH:13][CH:14]=1)=[N:10][N:9]([CH3:15])[C:8]=2[S:16]([NH2:19])(=[O:18])=[O:17]参加物
4
実験手順
A mixture comprising 62 g (221 mmol) of 4-cyclopropylmethoxy-2-methyl-2H-indazole-3-sulfonamide, 120 ml of acetic acid and 120 ml of concentrated hydrochloric acid, was stirred at 80° C. for one hour. After concentrating acetic acid.hydrochloric acid, the mixture was poured into ice water. Crystals were collected by filtration and washed with water. Further, the crystals were washed with IPE and dried to obtain 35.1 g (yield: 70%) of the desired product. Melting point: 180°-181° C.
後処理
- concentrationAfter concentrating acetic acid
- additionhydrochloric acid, the mixture was poured into ice water
- filtrationCrystals were collected by filtration
- washwashed with water
- washFurther, the crystals were washed with IPE
- customdried
出典と根拠
- ORDレコード
- ord-4dd86f73a12b495485b23d04147e256b
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05670452
反応ノート
読み込み中…