Hydrochloric Acid → 3-(2-Methoxypyrimidin-5-yl)prop-2-enoic acid
反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]([O:13]C)=[O:12])=[CH:5][N:4]=1.[OH-].[K+].Cl>CO>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12])=[CH:5][N:4]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
To 1.26 g of methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate were added 40 ml of methanol and 3.25 ml of a 4N potassium hydroxide aqueous solution, and the mixture was stirred at 50° C. for 2 hours. To the reaction mixture was added 0.5N hydrochloric acid, and the solution was extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure to give 1.12 g (6.22 mmol) of (E)-3-(2-methoxy-5-pyrimidinyl)acrylic acid.
後処理
- extractionthe solution was extracted with ethyl acetate
- washThe ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e65df0f16b6d445db93dc84f11b0c931
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05670492
反応ノート
読み込み中…