Ammonia → HCID 22909360、化合物

HRID 1379041ノート

反応式

HRID 1379041 の反応式
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]2[C:30](=[O:31])[C:29]3[CH:32]=[CH:33][CH:34]=[C:27]4[C:28]=3[C:23](=[CH:24][CH:25]=[CH:26]4)[C:22]2=[O:35])[CH2:15][CH2:14]1)(O)=[O:2].CS([O-])(=O)=O.ClC1C=CC=C[N+:43]=1C.N>CN1CCCC1>[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]2[C:30](=[O:31])[C:29]3[CH:32]=[CH:33][CH:34]=[C:27]4[C:28]=3[C:23](=[CH:24][CH:25]=[CH:26]4)[C:22]2=[O:35])[CH2:15][CH2:14]1)(=[O:2])[NH2:43]

参加物

5

反応物 3

HCID 222AmmoniaHCID 9834448HCID 9834448、化合物HCID 22909437HCID 22909437、化合物

生成物 1

HCID 22909360HCID 22909360、化合物

試薬・触媒・溶媒 1

HCID 84541-Methylpyrrolidine溶媒

実験手順

2.1 g of 2-[2-(4-(5-carboxy-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione are suspended in 100 ml of N-methylpyrrolidine. 3.2 g of 2-chloro-1-methylpyridinium methanesulfonate are then added and the mixture is stirred at room temperature for 12 hours. Dried NH3 gas is passed into the resulting solution until it is saturated and the mixture is stirred again for 10 hours. Customary working up gives 2-[2-(4-(5-carbamoyl-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione.

後処理

  1. stirringthe mixture is stirred again for 10 hours

出典と根拠

ORDレコード
ord-33588121d25c4338aeaf7bee4ee792bb
出典データセット
uspto-grants-1997_09
特許番号
US05670511

反応ノート

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