Water → 1-(4-Cyanophenyl)-5-[4-(methylthio)phenyl]-3-(trifluoromethyl)pyrazole

HRID 1379097

反応式

HRID 1379097 の反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][C:11](=O)[C:12]([F:15])([F:14])[F:13])=[CH:5][CH:4]=1.Cl.[C:19]([C:21]1[CH:26]=[CH:25][C:24]([NH:27][NH2:28])=[CH:23][CH:22]=1)#[N:20].O>C(O)(=O)C.CN(C)C=O>[C:19]([C:21]1[CH:26]=[CH:25][C:24]([N:27]2[C:9]([C:6]3[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=3)=[CH:10][C:11]([C:12]([F:15])([F:14])[F:13])=[N:28]2)=[CH:23][CH:22]=1)#[N:20]

参加物

6

反応物 3

HCID 962WaterHCID 107301701,3-Butanedione, 4,4,4-trifluoro-1-[4-(methylthio)phenyl]-HCID 162129624-Cyanophenylhydrazine Hydrochloride

生成物 1

HCID 229096971-(4-Cyanophenyl)-5-[4-(methylthio)phenyl]-3-(trifluoromethyl)pyrazole収率 101.4%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
110 °C

実験手順

A mixture of 1-[4-(methylthio)phenyl]-4,4,4-trifluorobutane-1,3-dione (1.8 g) and 4-cyanophenylhydrazine hydrochloride (1.2 g) in acetic acid (30 ml) and N,N-dimethylformamide (1 ml) was stirred at 110° C. for 3 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and evaporated to give a brown powder of 1-(4-cyanophenyl)-5-[4-(methylthio)phenyl]-3-(trifluoromethyl)pyrazole (2.5 g).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-8bd5a541242946eda9a4ff5346292f29
出典データセット
uspto-grants-1997_09
特許番号
US05670533

関連ノート

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