Hydrochloric Acid → HCID 22909698、化合物

反応式

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:25](OCC)=[O:26])=[N:11]2)=[CH:6][CH:5]=1)([OH:3])=[O:2].C[O-].[Na+].Cl.C([NH2:36])=O>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:22])=[O:23])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:25]([NH2:36])=[O:26])=[N:11]2)=[CH:8][CH:9]=1)([OH:3])=[O:2]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 713Formamide

HCID 10942334Sodium Methoxide

HCID 22909684HCID 22909684、化合物

生成物 1

HCID 22909698HCID 22909698、化合物

反応条件

温度: 45 °C

実験手順

A mixture of ethyl 1-(4-carboxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylate (3.9 g) and sodium methoxide (3 g) in formamide (40 ml) was stirred at 45° C. for 3 hours. The mixture was poured into a mixture of ice-water and hydrochloric acid. The precipitates were collected, washed with water, and dried to give crystals of 1-(4-carboxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxamide (3.2 g).

後処理

customThe precipitates were collected
washwashed with water
customdried

出典と根拠

ORDレコード: ord-79dea35f5e6a4aaa8f21de19407806d2
出典データセット: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05670533

反応ノート

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