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Hydrochloric Acid → 1-(4-Chlorophenyl)-3-(dimethylamino)propan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | P-Chloroacetophenone | HCID 7467 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | 1-Propanone, 1-(4-chlorophenyl)-3-(dimethylamino)-, hydrochloride (1:1) | HCID 200370 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(4-Chlorophenyl)-3-(dimethylamino)propan-1-one | HCID 200371 | — |
反応手順
4'-Chloro-3-dimethylaminopropiophenone is prepared by treating 4'-chloro-3-dimethylaminopropiophenone hydrochloride with aqueous base to remove the HCl. The free amine is extracted into diethyl ether and recovered by evaporation of the solvent. The hydrochloride salt is prepared by the method of Maxwell in Org. Synth. Coll. Vol. III, 305-306. Thus, a mixture of 4-chloroacetophenone, dimethylamine hydrochloride, and paraformaldehyde is refluxed for 2-4 hours in 95% ethanol with a small amount of added hydrochloric acid. The solid product is obtained after adding acetone and cooling overnight.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05670564 |
| 出典データセット | uspto-grants-1997_09 |
| ORD ID | ord-56f9b76dbf344b45980844846a6922d9 |
| 出典メモ | uspto-grants-1997_09 |