Methyl Acrylate → 4-Morpholinepropanoic acid, methyl ester

HRID 1379395

反応式

HRID 1379395 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9]>ClCCl>[N:1]1([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 7294Methyl AcrylateHCID 8083Morpholine

生成物 1

HCID 1013734-Morpholinepropanoic acid, methyl ester収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 4.9 ml (56 mmol) of morpholine in 50 ml of dichloromethane was treated dropwise with 5.0 ml (56 mmol) of methyl acrylate. The resulting solution was allowed to stand at ambient temperature for 3 days, after which it was concentrated in vacuo to an oil. Chromatography on silica gel using 0.5% methanol/2% isopropylamine in chloroform provided 9.54 g (99%) of the desired compound as a colorless liquid.

後処理

  1. concentrationafter which it was concentrated in vacuo to an oil

出典と根拠

ORDレコード
ord-26e81143862744a9b56f0ed9b6f2f8d3
出典データセット
uspto-grants-1997_09
特許番号
US05670675

関連ノート

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