N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine → N-(1-((2R,3S,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

HRID 1379773ノート

反応式

HRID 1379773 の反応式
[F:1][C@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:25]=[CH:24][C:14]([NH:15][C:16](=[O:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:13][C:11]1=[O:12].C(NC1C=CN([C@@H]2O[C@H](CO[C:46]([C:63]3[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=3)([C:55]3[CH:60]=[CH:59][C:58]([O:61][CH3:62])=[CH:57][CH:56]=3)[C:47]3[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][CH:48]=3)[C@@H](O)C2)C(=O)N=1)(=O)C1C=CC=CC=1>>[CH3:62][O:61][C:58]1[CH:57]=[CH:56][C:55]([C:46]([O:9][CH2:8][C@H:5]2[O:4][C@@H:3]([N:10]3[CH:25]=[CH:24][C:14]([NH:15][C:16](=[O:23])[C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[N:13][C:11]3=[O:12])[C@@H:2]([F:1])[C@@H:6]2[OH:7])([C:63]2[CH:64]=[CH:65][CH:66]=[CH:67][CH:68]=2)[C:47]2[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][CH:48]=2)=[CH:60][CH:59]=1

参加物

3

反応物 2

HCID 2724490N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidineHCID 54266479N4-Benzoyl-2'-deoxy-2'-fluoro-b-D-arabinocytidine

生成物 1

HCID 70700565N-(1-((2R,3S,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

実験手順

This compound is prepared from 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N4 -benzoylcytosine by the same procedure used for the preparation of N4 -benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine.

出典と根拠

ORDレコード
ord-ddf24c9cfde04cab8577c84c8f8c05f3
出典データセット
uspto-grants-1997_09
特許番号
US05672697

反応ノート

読み込み中…