Methyl Acrylate → methyl 3-(N-vinylformamido)propionate

HRID 1379897

反応式

HRID 1379897 の反応式
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=[CH2:3].[CH:7]([NH:9][CH:10]=[O:11])=[CH2:8]>C1(=O)C=CC(=O)C=C1.C[O-].[Na+]>[CH:7]([N:9]([CH2:3][CH2:2][C:1]([O:5][CH3:6])=[O:4])[CH:10]=[O:11])=[CH2:8]

参加物

5

反応物 2

HCID 7294Methyl AcrylateHCID 83191N-Vinylformamide

生成物 1

HCID 10964771methyl 3-(N-vinylformamido)propionate収率 92%

試薬・触媒・溶媒 2

HCID 4650Quinone触媒HCID 10942334Sodium Methoxide触媒

実験手順

To a 1000 mL three-neck round bottom flask equipped with a cold water condenser and stirrer was added 215 grams (2.5 moles) of methyl acrylate, 195 grams (2.75 moles) of N-vinylformamide, and 0.1 gram of benzoquinone. The mixture was stirred at ambient temperature for two minutes and 1.5 grams sodium methoxide was added in one portion. The mixture was stirred for approximately 2 hours at ambient temperature and allowed to stand overnight. The reaction mixture was distilled under vacuum and 361 grams of product (92% yield) boiling at 75° C. (0.8 mm Hg) was collected for analysis. 1H NMR analysis confirmed the identity of the 3-N-vinylformamido adduct.

後処理

  1. customTo a 1000 mL three-neck round bottom flask equipped with a cold water condenser and stirrer
  2. stirringThe mixture was stirred for approximately 2 hours at ambient temperature
  3. waitto stand overnight

出典と根拠

ORDレコード
ord-94269b9c76ae47b491e8704996ee4077
出典データセット
uspto-grants-1997_09
特許番号
US05672731

関連ノート

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