HCID 11821736、化合物 → alpha-(Trifluoromethyl)-p-isobutylphenylacetic acid
反応式
[F:1][C:2]([F:22])([F:21])[C:3]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([CH3:20])[CH3:19])=[CH:13][CH:12]=1)(C(F)(F)F)[C:4]([OH:6])=[O:5].FC(F)(F)C(C1C=CC=CC=1)(C(F)(F)F)C(O)=O>>[F:1][C:2]([F:21])([F:22])[CH:3]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([CH3:19])[CH3:20])=[CH:13][CH:12]=1)[C:4]([OH:6])=[O:5]参加物
3
実験手順
Reaction was carried out in the same manner as in Example 1, except that methyl ester of α,α-bis(trifluoromethyl)-p-isobutylphenylacetic acid obtained in Reference Example 3 was used in place of methyl ester of α,α-bis(trifluoromethyl)phenylacetic acid obtained in Reference Example 2, whereby α-(trifluoromethyl)-p-isobutylphenylacetic acid was obtained in yield of 43%.
後処理
- customReaction
- customobtained in Reference Example 3
- customobtained in Reference Example 2