1,1′-(1,4-Butanediyl)bis[1-phenylphosphine] → HCID 53960761、化合物
反応式
[CH3:1][C@@H:2]([CH2:6][CH2:7][CH:8](O)[C:9]([CH3:11])=[CH2:10])[CH2:3][CH2:4][OH:5].C1(PCCCCPC2C=CC=CC=2)C=CC=CC=1>[Pd](Cl)Cl.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[CH3:1][C@@H:2]([CH2:6][CH:7]=[CH:8][C:9]([CH3:11])=[CH2:10])[CH2:3][CH2:4][OH:5]参加物
4
反応条件
- 温度
- 150 °C
実験手順
(S)-3,7-dimethyl-6-hydroxy-7-octene-1-ol (I) (10.0 g, 58.1 mmol), bis(triphenylphosphine) palladium chloride (40.8 mg, 0.058 mmol), and 1,4-bisphenylphosphinobutane (1.24 g, 2.91 mmol) were placed in a 50 ml three neck distillation flask provided with a thermometer and a vacuum distilling apparatus having a side arm. The mixture was then heated for 6 hours with stirring at a reaction temperature of 150° C. under a reduced pressure of 25 mmHg while distilling dienes which is to be produced. 7.3 g (115° to 120° C./25 mmHg) of (S)-3,7-dimethyl-5,7-octadiene-1-ol (II) was obtained in 82% yield.