Acetic Acid → 2,3-Dihydro-1,4-benzodioxin-2-acetic acid

HRID 1380043

反応式

HRID 1380043 の反応式
C(C[CH:4]1[O:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[O:6][CH2:5]1)#N.[C:14]([OH:17])(=[O:16])[CH3:15].S(=O)(=O)(O)O>O>[O:6]1[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[O:9][CH2:4][CH:5]1[CH2:15][C:14]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 2675312-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

生成物 1

HCID 2675342,3-Dihydro-1,4-benzodioxin-2-acetic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 175 g 2-cyanomethyl 1,4-benzodioxan, 250 ml water, 250 ml acetic acid and 100 ml concentrated sulphuric acid are heated to reflux for 48 hours. The reaction mixture is then poured in 5000 ml water and the whole is kept under stirring. The thus found crystalls are filtered, washed with water and dried, giving rise to 172 g (1,4-benzodioxan-2yl)acetic acid melting at 95°.

後処理

  1. temperatureare heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe thus found crystalls are filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-f16d132e7bbe4e49b7993789be49112e
出典データセット
uspto-grants-1986_04
特許番号
US04579845

関連ノート

読み込み中…