Piperazine → 1-(3-Piperazinylpropyl)-3-n-hexylurea

HRID 1380199ノート

反応式

HRID 1380199 の反応式
Cl[CH2:2][CH2:3][CH2:4][NH:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:7].[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C(O)C>[N:15]1([CH2:2][CH2:3][CH2:4][NH:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:7])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

参加物

4

反応物 2

HCID 4837PiperazineHCID 136067321-(3-Chloropropyl)-3-n-hexylurea

生成物 1

HCID 571432471-(3-Piperazinylpropyl)-3-n-hexylurea収率 39%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1-(3-chloropropyl)-3-n-hexylurea (11.0 g; 50 mmole), piperazine (43.0 g; 500 mmole) and reagent ethanol (250 ml) was refluxed for 2 hours. The solvent was removed in vacuo, and the solid residue was dissolved in water. The resulting solution was extracted with methylene chloride, concentrated in vacuo, and the residue was chromatographed on silica gel to give 1-(3-piperazinylpropyl)-3-n-hexylurea as a light yellow oil (6.7 g; 39% yield).

後処理

  1. temperaturewas refluxed for 2 hours
  2. customThe solvent was removed in vacuo
  3. dissolutionthe solid residue was dissolved in water
  4. extractionThe resulting solution was extracted with methylene chloride
  5. concentrationconcentrated in vacuo
  6. customthe residue was chromatographed on silica gel

出典と根拠

ORDレコード
ord-d0f86b9766324726a753e3dba896e77d
出典データセット
uspto-grants-1986_04
特許番号
US04579947

反応ノート

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