Methanol → HCID 136332138、化合物

HRID 1380311ノート

反応式

HRID 1380311 の反応式
[OH:1][N:2]=[C:3]([CH3:18])[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[C:11](=[O:17])[CH2:10][CH2:9]2)=O.[NH2:19][NH:20][C:21]([NH2:23])=[S:22].CO.O>C(O)(=O)C>[OH:1][N:2]=[C:3]([CH3:18])[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[C:11](=[O:17])[CH2:10][CH2:9]2)=[N:19][NH:20][C:21]([NH2:23])=[S:22]

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 2723789ThiosemicarbazideHCID 73666243HCID 73666243、化合物

生成物 1

HCID 136332138HCID 136332138、化合物収率 26.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 6-(2-hydroxyiminopropionyl)-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline (1 g), thiosemicarbazide (0.48 g), methanol (10 ml), water (5 ml) and acetic acid (0.1 ml) was refluxed for 13 hours with stirring. After cooling, the resulting precipitates were collected by filtration, washed successively with ethanol, water and ethanol, and then dried to give 0.34 g of 6-(2-hydroxyimino-1-thiosemicarbazonopropyl)-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline.

後処理

  1. temperaturewas refluxed for 13 hours
  2. temperatureAfter cooling
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration
  5. washwashed successively with ethanol, water and ethanol
  6. customdried

出典と根拠

ORDレコード
ord-cd56ec2356cd43809b308a87e3d511e4
出典データセット
uspto-grants-1986_04
特許番号
US04581356

反応ノート

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