Potassium Carbonate → 1-Butyl-3-isopropyl-6-chlorouracil

HRID 1380402

反応式

HRID 1380402 の反応式
C(=O)([O-])[O-].[K+].[K+].C(OS([C:15]1[CH:20]=[CH:19][C:18](C)=CC=1)(=O)=O)CCC.[CH:22]([N:25]1[C:30](=[O:31])[CH:29]=[C:28]([Cl:32])[NH:27][C:26]1=[O:33])([CH3:24])[CH3:23]>CN(C)C=O>[CH2:15]([N:27]1[C:28]([Cl:32])=[CH:29][C:30](=[O:31])[N:25]([CH:22]([CH3:24])[CH3:23])[C:26]1=[O:33])[CH2:20][CH2:19][CH3:18]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 13066Butyl-p-toluenesulfonateHCID 8201076-Chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

生成物 1

HCID 233268771-Butyl-3-isopropyl-6-chlorouracil収率 98.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

16.6 g (0.12 mole) of potassium carbonate and 24 g (0.105 mole) of butyl-p-toluene sulphonate are added to a solution of 19 g (0.10 mole) of 3-isopropyl-6-chlorouracil in 200 ml of dimethyl formamide. The mixture is heated for 1 hour to 80° C. After evaporation of the solvent, the residue is taken up in water, followed by extraction with CH2Cl2. The extract is dried over Na2SO4 and the solvent is evaporated, leaving 24 g of a pale yellow oily product.

後処理

  1. temperatureThe mixture is heated for 1 hour to 80° C
  2. customAfter evaporation of the solvent
  3. extractionfollowed by extraction with CH2Cl2
  4. dry with materialThe extract is dried over Na2SO4
  5. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-5b58ab43a8f7478da0398adfb7584e49
出典データセット
uspto-grants-1986_04
特許番号
US04581451

関連ノート

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