4,6-Nonanedione → 4-(5,7-Dipropyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-piperazinecarboxylic acid, ethyl ester

HRID 1380521ノート

反応式

HRID 1380521 の反応式
[NH2:1][C:2]1[NH:3][C:4]([N:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9][CH2:8]2)=[N:5][N:6]=1.[CH3:18][CH2:19][CH2:20][C:21](=O)[CH2:22][C:23](=O)[CH2:24][CH2:25][CH3:26]>C(O)(=O)C>[CH2:20]([C:21]1[CH:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:6]2[N:5]=[C:4]([N:7]3[CH2:8][CH2:9][N:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:11][CH2:12]3)[N:3]=[C:2]2[N:1]=1)[CH2:19][CH3:18]

参加物

4

反応物 2

HCID 264544,6-NonanedioneHCID 1784733584-(5-amino-4H-1,2,4-triazol-3-yl)-1-piperazinecarboxylic acid, ethyl ester

生成物 1

HCID 136860144-(5,7-Dipropyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-piperazinecarboxylic acid, ethyl ester収率 93.9%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 4.48 g (0.02 moles) of 4-(5-amino-4H-1,2,4-triazol-3-yl)-1-piperazinecarboxylic acid, ethyl ester, 3.12 g (0.02 moles) of 4,6-nonanedione and 50 ml of glacial acetic acid was refluxed for 12 hours. The resulting solution was evaporated to dryness in vacuo. The residue was partitioned and treated as described in Example 12 and gave 6.77 g of the desired product as colorless crystals, mp 130°-132° C.

後処理

  1. temperaturewas refluxed for 12 hours
  2. customThe resulting solution was evaporated to dryness in vacuo
  3. customThe residue was partitioned
  4. additiontreated

出典と根拠

ORDレコード
ord-be58f9a26e5748d680e52bd587380267
出典データセット
uspto-grants-1986_04
特許番号
US04582833

反応ノート

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