Water → HCID 178457773、化合物

HRID 1380571ノート

反応式

HRID 1380571 の反応式
[Cl:1][C:2]1=[C:3]([Cl:9])[C:4]([O:6][C:7]1=[O:8])=[O:5].[CH3:10][CH:11]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:17][CH:16]=1)[CH2:12][NH2:13].O>C(O)(=O)C>[CH3:10][CH:11]([CH2:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([CH3:22])([CH3:24])[CH3:23])=[CH:19][CH:20]=1)[CH2:12][N:13]=[C:4]([OH:5])/[C:3](/[Cl:9])=[C:2](/[Cl:1])\[C:7]([OH:6])=[O:8]

参加物

5

反応物 3

HCID 962WaterHCID 70728Dichloromaleic anhydrideHCID 132903003-(4-tert-Butylphenyl)-2-methylpropan-1-amine

生成物 1

HCID 178457773HCID 178457773、化合物収率 41.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

16.7 g (0.1 mol) of dichloromaleic anhydride and 20.5 g (0.1 mol) of 2-methyl-3-(4-tert.-butylphenyl)-propylamine are stirred in 100 ml of glacial acetic acid under reflux for 4 hours. 100 ml of water are added, the oil which has separated out is extracted with methylene chloride, the methylene chloride phase is concentrated and the residue is recrystallized from ethanol. 14.6 g (41.2% of theory) of dichloromaleic acid N-[2-methyl-3-(4-tert.-butylphenyl)-propyl]-imide of melting point 64°-65° C. are obtained.

後処理

  1. temperatureunder reflux for 4 hours
  2. customthe oil which has separated out
  3. extractionis extracted with methylene chloride
  4. concentrationthe methylene chloride phase is concentrated
  5. customthe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-0757c7d5569f4122929dde6c4dc20450
出典データセット
uspto-grants-1986_04
特許番号
US04582849

反応ノート

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