Sodium Methoxide → 2-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

HRID 1380596

反応式

HRID 1380596 の反応式
[CH3:1][O-:2].[Na+].Br[C:5]([CH3:17])([CH3:16])[C:6]([C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1)=[O:7]>CO>[CH3:16][C:5]1([CH3:17])[O:7][C:6]1([O:2][CH3:1])[C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 114599841-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]-

生成物 1

HCID 201925252-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

95.1 g (1.76 mols) of sodium methylate are dissolved in 600 ml of methanol, and 437.1 g (1.60 mols) of 2-bromo-2-methyl-1-[4-(methylthio)-phenyl]-propan-1-one, dissolved in 300 ml of methanol, are added dropwise to this solution at reflux temperature. The methanol is then removed by distillation. The residue is poured into ice water, and the mixture is extracted with diethyl ether. The ether solution is washed with water, dried over Na2SO4 and concentrated. The crystals obtained are purified by vacuum distillation.

後処理

  1. additionare added dropwise to this solution
  2. temperatureat reflux temperature
  3. customThe methanol is then removed by distillation
  4. additionThe residue is poured into ice water
  5. extractionthe mixture is extracted with diethyl ether
  6. washThe ether solution is washed with water
  7. dry with materialdried over Na2SO4
  8. concentrationconcentrated
  9. customThe crystals obtained
  10. distillationare purified by vacuum distillation

出典と根拠

ORDレコード
ord-623991528b314e8bad08a3849278be8e
出典データセット
uspto-grants-1986_04
特許番号
US04582862

関連ノート

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