1-Propanone, 2-chloro-1-(4-chlorophenyl)-2-methyl- → 2-(4-Chlorophenyl)-3,3-dimethyl-2-methoxyoxirane

HRID 1380599ノート

反応式

HRID 1380599 の反応式
[CH3:1][O-:2].[Na+].Cl[C:5]([CH3:16])([CH3:15])[C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=[O:7]>CO>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2([O:2][CH3:1])[C:5]([CH3:16])([CH3:15])[O:7]2)=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 5873561-Propanone, 2-chloro-1-(4-chlorophenyl)-2-methyl-HCID 10942334Sodium Methoxide

生成物 1

HCID 122808342-(4-Chlorophenyl)-3,3-dimethyl-2-methoxyoxirane

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

57.0 g (1.056 mols) of sodium methylate are dissolved in 360 ml of methanol, and 208.4 g (0.96 mol) of 2-chloro-1-(4-chlorophenyl)-2-methylpropan-1-one are added dropwise to this solution at reflux temperature. The methanol is then removed by distillation. The residue is poured into ice water and the mixture is extracted with diethyl ether. The ether solution is washed with water, dried over Na2SO4 and concentrated. The resulting oil is purified by vacuum distillation.

後処理

  1. temperatureat reflux temperature
  2. customThe methanol is then removed by distillation
  3. additionThe residue is poured into ice water
  4. extractionthe mixture is extracted with diethyl ether
  5. washThe ether solution is washed with water
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated
  8. distillationThe resulting oil is purified by vacuum distillation

出典と根拠

ORDレコード
ord-5175ec569d2c4e839f19fd51131cb333
出典データセット
uspto-grants-1986_04
特許番号
US04582862

反応ノート

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