Methylamine → 3-Methoxy-N-methyl-4-(7H-purin-8-yl)benzamide
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1.[CH3:21]N>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11][CH3:21])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1参加物
3
実験手順
Forty milliliters of ethanolic methylamine solution were added to 0.42 gm of 8-(2'-methoxy-4'-chlorocarbonylphenyl)-purine hydrochloride (see Example 43), with cooling, and the mixture was refluxed for 30 minutes. It was then concentrated by evaporation, and the product was purified by column chromatography on silica gel [eluant: methylene chloride/ethanol (8:2)].
後処理
- temperaturewith cooling
- temperaturethe mixture was refluxed for 30 minutes
- concentrationIt was then concentrated by evaporation
- customthe product was purified by column chromatography on silica gel [eluant: methylene chloride/ethanol (8:2)]
出典と根拠
- ORDレコード
- ord-a4137e4a4a544e069a63a7165fad9f9c
- 出典データセット
- uspto-grants-1986_04
- 特許番号
- US04582837
反応ノート
読み込み中…