HCID 20184509、化合物 → HCID 20184521、化合物

HRID 1380762ノート

反応式

HRID 1380762 の反応式
[NH:1]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1)C(C)=O>Cl>[NH2:1][C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1

参加物

3

反応物 1

HCID 20184509HCID 20184509、化合物

生成物 1

HCID 20184521HCID 20184521、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
80 °C

実験手順

Five grams (13.3 mmol) of 5-acetamino-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole were suspended in 150 ml of concentrated hydrochloric acid and stirred at 80° C. for two hours. After cooling, the crude product precipitated was subjected to suction filtration and chromatographed on 500 gm of aluminium oxide (neutral) (eluant: methylene chloride with 2.5% ethanol).

後処理

  1. temperatureAfter cooling
  2. customthe crude product precipitated
  3. filtrationwas subjected to suction filtration
  4. customchromatographed on 500 gm of aluminium oxide (neutral) (eluant: methylene chloride with 2.5% ethanol)

出典と根拠

ORDレコード
ord-cb051754562b4ab1aab842a5ea9d7e84
出典データセット
uspto-grants-1986_04
特許番号
US04582837

反応ノート

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