Methylamine → HCID 20184582、化合物

HRID 1380766ノート

反応式

HRID 1380766 の反応式
C[O:2][C:3]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1)=O.[CH3:27][NH2:28]>>[CH3:27][NH:28][C:3]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[CH:14][C:13]=3[O:23][CH3:24])[NH:11][C:7]=2[CH:6]=1)=[O:2]

参加物

3

反応物 2

HCID 6329MethylamineHCID 20184489HCID 20184489、化合物

生成物 1

HCID 20184582HCID 20184582、化合物収率 67%

実験手順

One and one-half grams (4.0 mmol) of 5-methoxycarbonyl-2-(2'-methoxy-4'-methanesulfonylamino-phenyl)-benzimidazole and 10 ml of methylamine were heated for four hours to 120° C. in a steel canister. Then, excess methylamine was evaporated off, and the residue was dissolved in a small amount of water and neutralized with concentrated hydrochloric acid. After the solution was evaporated, the crude product obtained was purified by chromatography (150 gm of silica gel; eluant: methylene chloride with 10% ethanol).

後処理

  1. customThen, excess methylamine was evaporated off
  2. dissolutionthe residue was dissolved in a small amount of water and neutralized with concentrated hydrochloric acid
  3. customAfter the solution was evaporated

出典と根拠

ORDレコード
ord-9f2fcd5777c1473da7d89946f2c114e8
出典データセット
uspto-grants-1986_04
特許番号
US04582837

反応ノート

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