Diethyl Sulfate → HCID 23324620、化合物
反応式
[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([S:10][CH3:11])[N:4]=1.S(OCC)(O[CH2:16][CH3:17])(=O)=O>>[CH2:16]([O:9][C:7]1[N:6]=[C:5]([S:10][CH3:11])[N:4]=[C:3]([CH2:2][Cl:1])[CH:8]=1)[CH3:17]参加物
3
実験手順
4-Chloromethyl-6-hydroxy-2-methylthio-pyrimidine [known from S. Cohen et al., J.Org. Chem. 27, 3545-3549 (1962)] is treated with diethyl sulphate analogously to the process described in Example 59 in order to produce 6-ethoxy-4-chloromethyl-2-methylthio-pyrimidine which is required as the starting material in Example 19. M.p. (after crystallization from water) 167°-171° C.; 1H-NMR (CDCl3): 1.40 (t, CH3) 2.56 (s, SCH3), 4.45 (q, CH2), 4.47 (s, CH2Cl), 6.55 (s, CH).
出典と根拠
- ORDレコード
- ord-c068e2efd13c4d228767d4a33392be91
- 出典データセット
- uspto-grants-1986_04
- 特許番号
- US04584295
反応ノート
読み込み中…