Acrylamide → 3-(Piperidin-1-yl)propanamide

HRID 1380904

反応式

HRID 1380904 の反応式
C(S)(=N)N.[NH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[C:11]([NH2:15])(=[O:14])[CH:12]=[CH2:13]>CCO>[N:5]1([CH2:13][CH2:12][C:11]([NH2:15])=[O:14])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

5

反応物 3

HCID 6579AcrylamideHCID 8082PiperidineHCID 178513445HCID 178513445、化合物

生成物 1

HCID 5667843-(Piperidin-1-yl)propanamide収率 75%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Carbamimidothioic acid, N'-cyano-N-[3-[4-(diphenylmethylene)-1-piperidinyl]-propyl]-, methyl ester. A solution of piperidine, 4-(diphenylmethylene) (0.10 mole) and acrylamide (8.95 g, 0.062 mole) in EtOH (50 ml) was refluxed overnight. This reaction mixture was filtered and concentrated. The resulting while solid residue was dissolved in CHCl3, washed with H2O (3×150 ml), dried (Na2SO4) and the solvent removed to give thick yellow oil. Crystallization from CH2Cl2 -i-Pr2O afforded 29.01 g (75%) of 1-piperidinepropanamide, 4-(diphenylmethylene)-; mp 105°-7° C.

後処理

  1. filtrationThis reaction mixture was filtered
  2. concentrationconcentrated
  3. dissolutionThe resulting while solid residue was dissolved in CHCl3
  4. washwashed with H2O (3×150 ml)
  5. dry with materialdried (Na2SO4)
  6. customthe solvent removed
  7. customto give thick yellow oil
  8. customCrystallization from CH2Cl2 -i-Pr2O

出典と根拠

ORDレコード
ord-1789272e3d394ccf8937f1b06bce883b
出典データセット
uspto-grants-1986_04
特許番号
US04584301

関連ノート

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