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Water → 2-(4-Chlorophenoxy)-1-(4-chlorophenyl)-2-methylpropan-1-one

HRID 1380923
ノート
印刷プレビュー

反応式

HRID 1380923 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].O.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25](Br)([CH3:27])[CH3:26])=[O:24])=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:25]([C:23]([C:20]2[CH:19]=[CH:18][C:17]([Cl:16])=[CH:22][CH:21]=2)=[O:24])([CH3:27])[CH3:26])=[CH:4][CH:3]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 962Water2 回HCID 46844-ChlorophenolHCID 11430Potassium CarbonateHCID 112999732-Bromo-1-(4-chlorophenyl)-2-methylpropan-1-one

生成物 1

HCID 198424902-(4-Chlorophenoxy)-1-(4-chlorophenyl)-2-methylpropan-1-one収率 85%

試薬・触媒・溶媒 1

HCID 1140
Toluene
溶媒
2 回

反応条件

温度
40 °C

実験手順

52 g (0.3982 mol) of p-chlorophenol and 55 g (0.3982 mol) of potassium carbonate in 400 ml of toluene are heated under reflux for 2 hours, using a water separator. The mixture is cooled to 40° C. and a solution of 2-bromo-prop-2-yl 4-chlorophenyl ketone in 170 ml of toluene is added dropwise. This reaction mixture is subsequently stirred at 100° C. for 5 hours and is then cooled, water is added and the organic phase is separated off. This phase is washed with dilute sodium hydroxide solution and water, dried over sodium sulphate and concentrated. 87 g (85% of theory) of crude 4-chlorophenyl 2-(p-chlorophenoxy)-prop-2-yl ketone are obtained and are further reacted directly. ##STR160##

後処理

  1. temperatureunder reflux for 2 hours
  2. temperatureis then cooled
  3. customthe organic phase is separated off
  4. washThis phase is washed with dilute sodium hydroxide solution and water
  5. dry with materialdried over sodium sulphate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-fcef4b0198d04eddb2296940c5f41692
出典データセット
uspto-grants-1986_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04584308

反応ノート

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