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Hydrochloric Acid → 4-Nitro-3-phenylheptanedioic acid dimethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl Acrylate | HCID 7294 | — |
| 反応物 | Benzenepropanoic acid, b-(nitromethyl)-, methyl ester | HCID 10537045 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | 4-Nitro-3-phenylheptanedioic acid dimethyl ester | HCID 13649246 | — |
反応手順
A solution of 356 g of 4-nitro-3-phenylbutanoic acid methyl ester, 138 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate and evaporated to give 4-nitro-3-phenylheptanedioic acid dimethyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04584313 |
| 出典データセット | uspto-grants-1986_04 |
| ORD ID | ord-3f4c7e6ec30141ae967858d614e0af35 |
| 出典メモ | uspto-grants-1986_04 |