Ethanol → Ethyl 3-[4-(trifluoromethyl)phenyl]prop-2-enoate

反応式

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[CH2:21]([O:10][C:9](=[O:11])[CH:8]=[CH:7][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:14])([F:15])[F:1])=[CH:13][CH:12]=1)[CH3:22]

参加物

反応物 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 749403-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid

生成物 1

HCID 53662772Ethyl 3-[4-(trifluoromethyl)phenyl]prop-2-enoate

実験手順

A suspension of 300 g of 4-trifluoromethylcinnamic acid (J. Org. Chem. 43:980 (1978)) and 25 ml of concentrated sulfuric acid in 1.7 liters of ethanol is heated to reflux for 24 hours. The solution is concentrated, cooled, and filtered to give as a white solid, 4-trifluoromethylcinnamic acid ethyl ester, mp 40°-41° C.