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Nitric Acid → 1-Benzyl-5-hydroxymethyl-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Hydroxymethyl-2-mercapto-1-benzylimidazole | HCID 178519845 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Benzyl-5-hydroxymethyl-1H-imidazole | HCID 2773235 | — |
反応手順
1-Benzyl-2-mercapto-5-hydroxymethyl-imidazole (7.5 g) is added in small portions to a mixture of water (18 ml) and concentrated nitric acid (7.5 g) at 35° C. The mixture is stirred for 3 hours and the pH of the reaction mixture adjusted to 9-10 with sodium hydroxide. 1-Benzyl-5-hydroxymethyl-imidazole is obtained, 3.8 g (60%), m.p. 131°-135° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04584383 |
| 出典データセット | uspto-grants-1986_04 |
| ORD ID | ord-f655f798f4df46de975004a0485c55f6 |
| 出典メモ | uspto-grants-1986_04 |